The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.Īn important indicator of acute pulmonary embolism (PE) of moderate to high severity is an acute increase in right ventricular pressure or size or decreased systolic function. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Agency for Healthcare Research and Quality. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the manuscript and its Supporting Information files.įunding: This project was supported by grant number R01HS025979 to AJW from the Agency for Healthcare Research and Quality ( ). Received: JAccepted: OctoPublished: November 18, 2021Ĭopyright: © 2021 Weekes et al. PLoS ONE 16(11):Įditor: Christophe Leroyer, Universite de Bretagne Occidentale, FRANCE (2021) Development and validation of a prognostic tool: Pulmonary embolism short-term clinical outcomes risk estimation (PE-SCORE). In the validation dataset, PE-SCORE zero had 8% outcome, whereas all patients with PE-SCORE of six and above had the primary outcome.Ĭitation: Weekes AJ, Raper JD, Lupez K, Thomas AM, Cox CA, Esener D, et al. As points increased, outcome proportions increased: a score of zero had 2% outcome, whereas scores of six and above had ≥ 69.6% outcomes. In the validation database, 26.6% had the primary outcome. Prognostic accuracy of logistic regression model versus PE-SCORE model: 0.83 (0.80, 0.86) vs. In the development database, 22.4% had the primary outcome. Logistic regression yielded a nine-variable model, then simplified to a nine-point tool (PE-SCORE): one point each for abnormal RV by echocardiography, abnormal RV by computed tomography, systolic blood pressure < 100 mmHg, dysrhythmia, suspected/confirmed systemic infection, syncope, medico-social admission reason, abnormal heart rate, and two points for creatinine greater than 2.0 mg/dL.